Injuries are an inherent part of the game of football, and the San Francisco 49ers are feeling the effects as they prepare for their upcoming matchup against the Los Angeles Rams. Head coach Kyle Shanahan has provided updates on several key players, revealing a challenging situation leading up to Week 3 of the NFL season.

There may not be two teams more injured than the Los Angeles Rams and San Francisco 49ers, which will have a big impact on Sunday’s game at SoFi Stadium. The 49ers are missing Christian McCaffrey, Deebo Samuel and possibly George Kittle,

After spending six seasons in red and gold, the former 49ers quarterback will be on the opposing sideline on Sunday in Los Angeles.

The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday’s game against the Los Angeles Rams

The San Francisco 49ers are officially listing tight end George Kittle as doubtful to play for their Week 3 divisional matchup against the Los Angeles Rams. Kittle is dealing with a hamstring injury and is now unlikely to play on Sunday.

The Los Angeles Rams and San Francisco 49ers are heading in different directions injury-wise as the week progresses. Two key Rams players are improving ahead of Sunday’s game, while the 49ers added three starters to the injury report on Thursday.