Louisville is a suburban town in Blount County, Tennessee. Its population was 4,384 at the 2020 census. It is included in the Knoxville, Tennessee Metropolitan Statistical Area. The Louisville area was settled in the early 1800s, and its situation on the Tennessee River helped it grow into a key flatboat and steamboat port. It was incorporated in 1851. The town's namesake is unknown, although some have suggested that its name was influenced by the French King Louis Philippe, who visited the area in the late 1790s. In 1974 Louisville's downtown was declared a national historic district by the National Register of Historic Places.