Long-read sequencing vs short-read sequencing
WEBJul 26, 2021 · Long-read sequencing. Long-read sequencing technologies are capable of reading longer lengths, between 5,000 and 30,000 base pairs. Therefore, they immediately address one of the main challenges faced by short-read sequencing. They sequence a single molecule, eliminating amplification bias, and …
What is multiplex PCR? - Front Line Genomics
WEBJul 26, 2021 · Multiplex PCR is a technique whereby PCR is used to amplify several different DNA sequences simultaneously. It is a type of target enrichment approach. It was first described in 1988 as a method to detect deletion mutations in the dystrophin gene – the largest known human gene. The dystrophin complex connects the …
A brief history of Next Generation Sequencing (NGS)
WEBJul 26, 2021 · 2000: Lynx Therapeutics Company launched the first of the NGS technologies, called Massively parallel signature sequencing (MPSS). The company was later bought by Illumina. 2004: 454 Life Sciences marketed a new generation pyrosequencing technology, called the Roche GS20. It …
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DNA Sequencing: How to Choose the Right Technology
WEBAug 6, 2021 · The global market for DNA sequencing is predicted to grow from $15.7 billion in 2021 to $37.7 billion by 2026. The rising prevalence of viral diseases, such as COVID-19, and the increasing cases of cancer globally are likely to drive genomic research and propel the industry at an even more rapid rate.
About - Front Line Genomics
WEBAddress: Ground Floor, Cromwell House, 15 Andover Road, Winchester, Hampshire, SO23 7BT. Telephone: +44 (0)208 191 8810. Email: [email protected]. At Front Line Genomics our mission is to deliver the benefits of genomics to patients faster. Our social mission drives everything we do.
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Sample Preparation for NGS – A Comprehensive Guide
WEBAug 21, 2024 · Step #3: Amplification. This is an optional step, but it is usually required. It is dependent on the application of NGS and the sample size. Amplification becomes essential to obtain enough coverage for reliable sequencing for samples with small amounts of starting material.
JAG2 Mutation – New cause for Muscular Dystrophy - Front Line …
WEBApr 19, 2021 · A mutation in a previously unexamined Notch ligand, JAG2, is found to cause a rare form of muscular dystrophy (MD) that is consistent across multiple countries and ethnic groups.It has a distinct pattern on muscle MRI that could be used for future diagnosis. In this recent study, 23 individuals from 13 families were investigated as having genetically unsolved MD and were found to have a ...
A longstanding mystery: How do identical twins arise?
WEBOct 1, 2021 · Scientists have discovered DNA methylation differences that are unique to identical twins, helping to unravel the exact molecular events that lead to division of a zygote.. Monozygotic twins, or identical twins, result from the fertilisation of a single egg with a single sperm.At some point during the very early pre-implantation stages of development, the zygote divides into two embryos.